OVER-EXPRESSION OF CYSTEINE LEUCINE RICH PROTEIN IS RELATED TO SAG RESISTANCE IN CLINICAL ISOLATES OF LEISHMANIA DONOVANI.

Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani.

BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable.Cysteine leucine rich protein (CLrP), was recognized as one of the overexpressed proteins in resistant isolates

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Objectivity, Social Sciences, and the Charge of Inferiority

This paper challenges the charge of inferiority, on the basis of objectivity, against the social sciences.The idea of objectivity is that facts about the pentair hose state of the world and entities in it are observed or studied without a taint of personal bias, value judgement or particular perspective.The social sciences are accused of falling sh

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Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip

Recent ficklewood photos advances in integrating microengineering and tissue engineering have enabled the creation of promising microengineered physiological models, known as organ-on-a-chip (OOC), for experimental medicine and pharmaceutical research.OOCs have been used to recapitulate the physiologically critical features of specific human tissue

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